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KMID : 0914820100100040196
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Journal of the Korean Gastric Cancer Association
2010 Volume.10 No. 4 p.196 ~ p.205
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Prognostic Significance of Preoperative Blood Transfusion in Stomach Cancer
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Kim Seok-Hwan
Lee Sang-Il
Noh Seung-Moo
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Abstract
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Purpose: We did a retrospective study to understand the prognostic effects of preoperative blood transfusions in stomach cancer surgery.
Materials and Methods: Data for 1,360 patients who underwent gastrectomy for stomach cancer between 2001 and 2009 were retrospectively reviewed. We analyzed factors that affect preoperative transfusion and clinicopathologic features. We also analyzed 5-year and overall survival rates of the transfusion and non transfusion subgroups.
Results: Sixty patients (4.4%) required blood transfusion within the preoperative period. The transfused group included patients who took aspirin or clopidogrel (P<0.001), with more advanced T stages (P<0.001), with more advanced nodal metastasis (P=0.00), and with more advanced stages (P=0.00) than the non transfusion group. On multivariate analysis, preoperative transfusion was a statistically significant negative influence on 5-year survival and overall survival rates (58.2% vs 79.9% (P=0.00), 58.2% vs 76.8% (P=0.00)). Applying Cox-regression analyses, blood transfusion did appear to have an effect on prognosis and on 5-year and overall survival rates.
Conclusions: We found a direct negative relation between preoperative transfusion and long term prognosis in patients receiving gastric cancer surgery.
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KEYWORD
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Stomach neoplasm, Blood transfusion, Prognosis
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